716 844
Table 1 – Baseline characteristics of patients who received chemotherapy plus radical nephroureterectomy versus chemotherapy alone for
metastatic upper tract urothelial carcinoma in unweighted and weighted study populations from the National Cancer Data Base, 2004–2012
Characteristics
Unweighted study population,
n
(%)
Weighted study population, %
Overall
CTx + RNU
CTx alone
SD (%)
Overall
CTx + RNU
CTx alone
SD (%)
Number of patients
1,035 (100)
398 (38.4)
637 (61.6)
–
–
–
–
–
Median age, yr (IQR)
68.0 (61.0–75.0) 67.0 (61.0–75.0) 68.0 (61.0–76.0)
5.2 68.0 (61.0–75.0) 68.0 (62.0–74.0) 68.0 (61.0–75.0)
0.6
Age category
7.2
<
70 yr
570 (55.1)
228 (57.3)
342 (53.7)
54.8
55.5
54.1
2.8
70 yr
465 (44.9)
170 (42.7)
295 (46.3)
45.2
44.5
45.9
Charlson comorbidity index
11.8
0
789 (76.2)
297 (74.6)
492 (77.2)
77.1
77.3
77.0
0.9
1
195 (18.9)
75 (18.9)
120 (18.9)
18.0
17.9
18.2
2
51 (4.9)
26 (6.5)
25 (3.9)
4.9
4.8
4.8
Gender
10.7
Male
616 (59.5)
224 (56.3)
392 (61.5)
59.2
59.3
59.1
0.4
Female
419 (40.5)
174 (43.7)
245 (38.5)
40.8
40.7
40.9
Race/ethnicity
13.7
Non-Hispanic White
952 (92.0)
372 (93.5)
580 (91.1)
92.1
92.1
92.0
0.5
Non-Hispanic Black
49 (4.7)
12 (3.0)
37 (5.8)
4.7
4.7
4.7
Other/unknown
34 (3.3)
14 (3.5)
20 (3.1)
3.2
3.2
3.3
Median income for ZIP code
16.9
Above median income
628 (60.7)
249 (62.6)
379 (59.5)
61.1
61.1
61.1
2.3
Below median income
370 (35.7)
142 (35.7)
228 (35.8)
35.7
35.8
35.5
Unknown
37 (3.6)
7 (1.7)
30 (4.7)
3.2
3.1
3.4
Educational attainment for ZIP code
20.3
Above median education
662 (64.0)
269 (67.6)
393 (61.7)
62.9
62.6
63.3
3.5
Below median education
337 (32.5)
123 (30.9)
214 (33.6)
33.9
34.4
33.3
Unknown
36 (3.5)
6 (1.5)
30 (4.7)
3.2
3.0
3.4
Insurance status
12.8
Medicare
583 (56.3)
221 (55.5)
362 (56.8)
56.8
56.6
57.0
3.2
Private insurance/managed care
370 (35.8)
151 (38.0)
219 (34.4)
35.3
35.5
35.2
Medicaid/other government
39 (3.8)
14 (3.5)
25 (3.9)
3.4
3.2
3.5
Not insured
24 (2.3)
8 (2.0)
16 (2.5)
2.5
2.5
2.4
Unknown
19 (1.8)
4 (1.0)
15 (2.4)
2.0
2.2
1.9
County category
11.1
Metropolitan county
831 (80.3)
320 (80.4)
511 (80.2)
80.3
80.5
80.2
3.0
Urban county
143 (13.8)
59 (14.8)
84 (13.2)
14.0
14.1
13.9
Rural county
17 (1.6)
7 (1.8)
10 (1.6)
1.6
1.6
1.6
Unknown
44 (4.3)
12 (3.0)
32 (5.0)
4.1
3.8
4.3
CoC facility type
19.7
Not academic/research program 642 (62.0)
270 (67.8)
372 (58.4)
63.5
64.1
62.9
2.5
Academic/research program
393 (38.0)
128 (32.2)
265 (41.6)
36.5
35.9
37.1
US census division for CoC facility
8.8
East
459 (44.4)
166 (41.7)
293 (46.0)
43.2
42.8
43.6
1.7
Central
434 (41.9)
176 (44.2)
258 (40.5)
43.0
43.3
42.6
West
142 (13.7)
56 (14.1)
86 (13.5)
13.8
13.9
13.8
Year of diagnosis
11.9
2004–2006
250 (24.1)
92 (23.1)
158 (24.8)
24.2
24.4
24.0
1.4
2007–2009
311 (30.1)
133 (33.4)
178 (27.9)
29.8
30.0
29.7
2010–2012
474 (45.8)
173 (43.5)
301 (47.3)
46.0
45.6
46.3
Primary tumor site
2.9
C65.9: renal pelvis
737 (71.2)
309 (77.6)
428 (67.2)
70.6
70.4
70.9
1.4
C66.9: ureter
298 (28.8)
89 (22.4)
209 (32.8)
29.4
29.6
29.1
Clinical T stage
19.2
cT2
123 (11.9)
36 (9.0)
87 (13.6)
11.4
11.3
11.5
1.3
cT3
375 (36.2)
163 (41.0)
212 (33.3)
37.6
37.9
37.3
Unknown
537 (51.9)
199 (50.0)
338 (53.1)
51.0
50.8
51.2
Clinical N stage
34.9
cN0
211 (20.4)
97 (24.4)
114 (17.9)
20.3
20.1
20.4
0.9
cN+
486 (47.0)
145 (36.4)
341 (53.5)
47.0
47.3
46.8
Unknown
338 (32.6)
156 (39.2)
182 (28.6)
32.7
32.6
32.8
Metastasis location
8.2
Extraregional lymph nodes only
96 (9.3)
39 (9.8)
57 (8.9)
8.6
8.4
8.8
1.5
Bone/visceral involvement
808 (78.1)
315 (79.1)
493 (77.4)
78.7
79.0
78.5
Unknown
131 (12.6)
44 (11.1)
87 (13.7)
12.7
12.6
12.7
CTx = chemotherapy; RNU = radical nephroureterectomy; SD = standardized difference; IQR = interquartile range; ZIP = zone improvement plan;
CoC = Commission on Cancer; US = United States.
E U R O P E A N U R O L O G Y 7 1 ( 2 0 1 7 ) 7 1 4 – 7 1 8
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