

Statistical analysis:
None.
Obtaining funding:
None.
Administrative, technical, or material support:
None.
Supervision:
Bex.
Other:
None.
Financial disclosures:
Axel Bex certifies that all conflicts of interest,
including specific financial interests and relationships and affiliations
relevant to the subject matter or materials discussed in the manuscript
(eg, employment/affiliation, grants or funding, consultancies, honoraria,
stock ownership or options, expert testimony, royalties, or patents filed,
received, or pending), are the following: Axel Bex has received company
speaker honoraria from Pfizer; has participated in trials for Pfizer
Europe; has participated in advisory boards for GlaxoSmithKline and
Novartis; is a company consultant for Pfizer and Novartis; and has
received grants/research support from Pfizer. Laurence Albiges has
received consulting/advisory fees from BMS, Pfizer, Novartis, Sanofi,
Amgen, Bristol-Myers Squibb, Bayer, and Cerulean; and research funding
from Pfizer and Novartis. Bo¨rje Ljungberg has received company speaker
honoraria from GlaxoSmithKline, Roche, Pfizer, and Novartis; has
participated in trials for GlaxoSmithKline, Medivation, Pfizer, and
Janssen R&D; and has been on advisory boards for Pfizer and
GlaxoSmithKline. Karim Bensalah has received grants/research support
from Pfizer and honoraria or consultation fees from Intuitive Surgical.
Milan Hora has received company speaker honoraria from Covidien,
Olympus, Janssen, and Astellas; has participated in trials for Janssen; and
has received grants/research support from Ipsen. Markus A. Kuczyk is a
stock shareholder of Bayer Healthcare, Astellas, Storz, Pfizer, Wyeth, and
Novartis; is a company consultant for Karl Storz, Coloplast, AstraZeneca,
Astellas, Storz, and Hexal; has received company speaker honoraria from
Pfizer, Astellas, Bayer, GlaxoSmithKline, Pierre Fabre, Janssen Cilag, and
Hexal; has participated in trials for the ProtecT Study, Millenium Study
C21004, Millenium Study C21005, Astellas, Ipsen, and Janssen; and has
received grants/research support fromWyeth and Pfizer. Thomas B. Lam
is a company consultant for and has received company speaker
honoraria from Pfizer, GlaxoSmithKline, Astellas, and Ipsen. Axel S.
Merseburger is a company consultant for Ipsen Pharma, Bayer, Astellas,
Janssen Cilag, Novartis, and Pfizer; has received company speaker
honoraria from Ipsen Pharma, Wyeth, Astellas, Novartis, Pfizer, and SEP;
has participated in trials for AstraZeneca, Bayer, Pfizer, TEVA, Novartis,
and Astellas; has received grants/research support fromWyeth; and has
participated in a company-sponsored speakers bureau for TEVA, Janssen,
Pfizer, Astellas, Ferring, and Novartis. Michael Staehler is a company
consultant for Pfizer, Novartis, GlaxoSmithKline, Roche, Astellas, and
Bayer; has received company speaker honoraria from Pfizer, Novartis,
GlaxoSmithKline, Roche, Astellas, Bayer, and Aveo; has participated in
trials for Pfizer, Novartis, GlaxoSmithKline, Roche, Bayer, Aveo, Wilex,
and Immatics; has received fellowships and travel grants from Pfizer,
Novartis, GlaxoSmithKline, Roche, and Bayer; and has received grants/
research support from Pfizer, Novartis, GlaxoSmithKline, Roche, Bayer,
and Aveo. In addition, he took part in the S-TRAC trial as an investigator
and is an author on the S-TRAC publication. Thomas Powles is a company
consultant for Novartis, Pfizer, and GlaxoSmithKline; has received
company speaker honoraria from Novartis, Pfizer, GlaxoSmithKline, and
Genentech; has participated in trials for GlaxoSmithKline, Pfizer, BMS,
Genentech, and Genetech; and has received grants/research support
from GlaxoSmithKline, Pfizer, and Novartis. Saeed Dabestani, Rachel H.
Giles, Fabian Hofmann, Lorenzo Marconi, and Alessandro Volpe have
nothing to disclose.
Funding/Support and role of the sponsor:
None.
Appendix A. Supplementary data
Supplementary data associated with this article can be
found, in the online version, at
http://dx.doi.org/10.1016/j. eururo.2016.11.034.
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