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allow prolonged periods of therapy

[81]

. Surgical excision of

BE nodules should be performed if pain persists despite

medical treatment, when the lesion causes ureteral

stricture, and for patients with a contraindication to

hormonal therapies or who refuse these drugs. The primary

goal of surgery should be complete removal of the bladder

nodule; consequently, when surgical treatment is chosen,

TUR alone should be avoided.

Author contributions:

Simone Ferrero had full access to all the data in the

study and takes responsibility for the integrity of the data and the

accuracy of the data analysis.

Study concept and design:

Leone Roberti Maggiore, Ferrero, Candiani,

Somigliana, Vigano` , Vercellini.

Acquisition of data:

Leone Roberti Maggiore, Ferrero, Candiani, Somigli-

ana, Vigano` , Vercellini.

Analysis and interpretation of data:

Leone Roberti Maggiore, Ferrero,

Somigliana, Vigano` , Vercellini.

Drafting of the manuscript:

Leone Roberti Maggiore, Somigliana, Vigano` ,

Vercellini.

Critical revision of the manuscript for important intellectual content:

Ferrero, Candiani, Somigliana, Vigano` , Vercellini.

Statistical analysis:

None.

Obtaining funding:

None.

Administrative, technical, or material support:

None.

Supervision:

None.

Other:

Leone Roberti Maggiore (figure and table preparation).

Financial disclosures:

Simone Ferrero certifies that all conflicts of

interest, including specific financial interests and relationships and

affiliations relevant to the subject matter or materials discussed in the

manuscript (eg, employment/affiliation, grants or funding, consultan-

cies, honoraria, stock ownership or options, expert testimony, royalties,

or patents filed, received, or pending), are the following: None.

Funding/Support and role of the sponsor:

None.

Appendix A. Supplementary data

Supplementary data associated with this article can be

found, in the online version, at

http://dx.doi.org/10.1016/j. eururo.2016.12.015

.

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